研究業績

2024

  1. Ogoshi T, Yatera K, Mukae H, Tsutsui M. Role of nitric oxide synthases in respiratory health and disease: insight from triple nitric oxide synthases knockout mice. Int J Mol Sci. 2024; 25(17), 9317; doi:<https://doi.org/10.3390/ijms25179317> https://doi.org/10.3390/ijms25179317 (IF 4.9)　

  2. Tsutsui M, Yatera K. Significance of nitric oxide derived from the nitric oxide synthases system in cardiovascular inter-organ cross-talk. J Pharmacol Exp Ther. 2024, Aug 23: JPET-MR-2024-002222. doi: 10.1124/jpet.124.002222 (IF 3.1) 

  3. Kubota H, Tsutsui M, Kuniyoshi K, Yamashita H, Shimokawa H, Sugahara K, Kakinohana M. Alleviated cerebral infarction in male mice lacking all nitric oxide synthase isoforms after middle cerebral artery occlusion. J Anesth 2024;38(1):44-56. doi: 10.1007/s00540-023-03271-8. (IF 2.8)　

  4. de Oliveira M.G.d., Britto-Junior J, Martins Dias L.G., Santos Pereira L.G., Chiavegatto S., Hermawan I., Shimokawa H., Tsutsui M., Antunes E., De Nucci G. Neurogenic-derived 6-nitrodopamine is the most potent endogenous modulator of the mouse urinary bladder relaxation. Nitric Oxide 2024;153:98-105. https://doi.org/10.1016/j.niox.2024.10.010. (IF 3.2)

2023

  1. Yanagihara N, Takada M, Ariyoshi H, Satoh N, Horishita T, Shao H, Tsutsui M, Kita T, Azuma K. Effects of pine nodule extract, 
Sho-ko-sen, on mental stress-induced changes in the autonomic nervous balance in young students. 
Current Topics in Pharmacology 2023, 27, 47-53 (IF 0.0)

  2. Abidin QHZ, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, Akaike T. Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism. Antioxidants 2023; 12(4): 868. doi: <https://doi.org/10.3390/antiox12040868> 10.3390/antiox12040868 (IF 7.675)

  3. Yamashita H, Matsuhara H, Tanaka H, Inagaki N, Tsutsui M. Oral allergy induction through skin exposure to previously tolerated food antigens in murine models. Journal of Pharmacological Sciences 2023; 152 (2023) : 76-85; (IF 3.578)

 

2022

  1. Ghosh A, Sumi MP, Tupta B, Okamoto T, Aulak K, Tsutsui M, Shimokawa H, Erzurum SC, Stuehr DJ. Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic. Redox Biology 2022; 56:102478. doi: 10.1016/j.redox.2022.102478 (IF 11.799)
  2. Nakachi S, Okamoto S, Tamaki K, Nomura I, Tomihama M, Nishi Y, Fukushima T, Tanaka Y, Morishima S, Imamura M, Maeda S, Tsutsui M, Matsushita M, Masuzaki H. Impact of anti-diabetic sodium-glucose cotransporter 2 inhibitors on tumor growth of intractable hematological malignancy in humans. Biomedicine & Pharmacotherapy 2022; 149: 112864 doi.org/10.1016/j.biopha.2022.112864 (IF 7.419)

 

2021

  1. Kato K, Tsutsui M, Noguchi S, Iha Y, Naito K, Ogoshi T, Nishida C, Tahara M, Yamashita H, Wang KY, Toyohira Y, Yanagihara N, Masuzaki H, Shimokawa H, Tanimoto A, Yatera K. Spontaneous Pulmonary Emphysema in Mice Lacking All Three Nitric Oxide Synthase Isoforms. Scientific Reports 11(1):22088, 2021 (IF 4.996)
  2. Furuzono S, Kubota T, Taura J, Konishi M, Naito A, Tsutsui M, Karasawa H, Kubota N, Kadowaki T. A Xanthene derivatives, DS20060511, attenuates Glucose Tolerance by Inducing Skeletal Muscle-Specific GLUT4 Translocation in Mice. Communication Biology 4(1): 994, 2021 (IF 6.548)
  3. Yamashita H, Shigemori A, Murata M, Tanaka H, Inagaki H, Tsutsui M, Kimura M. Impact of orally-administered oligosaccharides in murine model of food allergy. Journal of Functional Foods 85: 104643, 2021 (IF 5.223)
  4. Shimamori Y, Mitsunaka S, Yamashita H, Suzuki T, Kitao T, Kubori T, Nagai H, Takeda S, and Ando H. Staphylococcal Phage in Combination with Staphylococcus epidermidis as a Potential Treatment for Staphylococcus aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants. Viruses 13(1): 7, 2021 (IF 5.818)

2020

  1. Ikumi Y, Shiroto T, Godo S, Saito H, Tanaka S, Ito A, Kajitani S, Monma Y, Miyata S, Tsutsui M, Shimokawa H. Important Role of Endothelium-Dependent Hyperpolarization in Coronary Microcirculation and Cardiac Diastolic Function in Mice. J Cardiovasc Pharmacol. 2020; 75(1): 31-40 (IF 3.271)
  2. Li X, Yanagihara N, Horishita T, Toyohira Y, Satoh N, Tsutsui T, Kita T.  Inhibitory effects of Sho-ju-sen and its component kumazasa leaves on catecholamine secretion induced by acetylcholine in cultured bovine adrenal medullary cells.  Current Topics in Phytochemistry 2020, 16, 105-114 (IF 0.000)
  3. Liu J, Iwata K, Zhu K, Matsumoto M, Asaoka N, Zhang X, Ibi M, Katsuyama M, Tsutsui M, Kato S, and Yabe-Nishimura C.  NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function.  Free Radical Biology and Medicine 2020; 147: 90-101 (IF 8.101)

2019

  1. Millman J, Okamoto S, Kimura A, Uema T, Higa M, Yonamine M, Namba T, Ogata E, Yamazaki S, Shimabukuro M, Tsutsui M, Matsushita M, Ikematsu S, Masuzaki H.  Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice.  European Journal of Nutrition 2019; Sep 10. doi: 10.1007/s00394-019-02088-0 (IF 4.865)

2018

  1. Ogoshi T, Tsutsui M, Kido T, Sakanashi M, Naito K, Oda K, Ishimoto H, Yamada S,Wang KY, Toyohira Y, Izumi H, Masuzaki H, Shimokawa H, Yanagihara N, Yatera K, Mukae H. Protectiverole of myelocytic nitric oxide synthases against hypoxic pulmonary hypertension in mice. Am J Respir Crit Care Med 2018; 198(2): 232-244 (IF 30.528)

2017

  1. Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina S, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M. Long-term dietary nitrite and nitrate deficiency causes metabolic syndrome, endothelial dysfunction, and cardiovascular death in mice. Diabetologia 2017; 60(6): 1138-1151 (IF 10.460)
  2. Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M,Abe K, Masuzaki H. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptor in brain striatum of high fat diet-induced obese mice. Diabetologia 2017; 60(8): 1502-1511 (IF 10.460)
  3. Satake Y, Satoh K, Nogi M, Omura J, Godo S, Miyata S, Saito H, Tanaka S, Ikumi Y, Yamashita S, Kaiho Y, Tsutsui M, Arai Y, Shimokawa H. Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice. Am J Physiol-Renal Physiol. 2017; 312: F33-F42 (IF 4.097)
  4. Li X, Horishita T, Toyohira Y, Shao H, Bai J, Bo H, Song X, Ishikane S, Yoshinaga Y, Satoh N, Tsutsui M, Yanagihara N. Inhibitory effects of pine nodule extract and its component, SJ-2, on acetylcholine-induced catecholamine secretion and synthesis in bovine adrenal medullary cells. J Pharmacol Sci. 2017; 133(4): 268-275 (IF 3.578)

2016

  1. Yoshimura T, Hamada T, Hijioka H, Souda M, Hatanaka K, Yoshioka T, Yamada S, Tsutsui M, Umekita, Y,  Nakamura N, Tanimoto A.  PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells.Oncotarget. 2016; doi: 10.18632/oncotarget.7529 (IF 5.168)
  2. Akata K, Yatera K, Wang K-Y, Naito K, Ogoshi T, Noguchi S, Kido T, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H.  Decreased bronchial eosinophilic inflammation and mucus hypersecretion in asthmatic mice lacking all nitric oxide synthase isoforms.Lung 2016; 194: 121-4  (IF 3.777)

2015

  1. Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki J, Oyadomari S, Shimabukuro M, Masuzaki H.  A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signaling in mouse islet.  Brit J Pharmacol.2015; 172: 4519-4534  (IF 9.473)
  2. Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki J, Oyadomari S, Shimabukuro M, Masuzaki H.  Gamma-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male.  Endocrinology. 2015; 156: 1242-1250 (IF 5.051)
  3. Tsutsui M, Tanimoto A, Tamura M, Mukae H, Yanagihara N, Shimokawa H, Otsuji Y.  Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice.  J Pharmacol Sci. 2015; 127: 42-52 (IF 3.578)
  4. Noguchi K, Matsuzaki T, Sakanashi M, Hamadate M, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M.  Effect of caffeine contained in a cup of coffee on microvascular function in heathy subjects.  J Pharmacol Sci. 2015; 127: 217-222  (IF 3.578)
  5. Shiroma A, Nishimura M, Nagamine H, Miyagi T, Hokama Y, Watanabe T, Murayama S, Tsutsui M, Tominaga D, Ishiuchi S.  Cerebellar contribution of pattern separation of human hippocampal memory circuits: analysis of cognitive impairment and benign cerebellar tumors.  Cerebellum 2015; doi:10.1007/s12311-015-0726-0 (IF 3.648)
  6. Li X, Toyohira Y, Inagaki H, Horishita T, Satoh N, Takahashi K, Cho N, Iinuma S, Ueno S, Tsutsui M, Sata M, Yanagihara N.  Effects of selective estrogen receptor modulators on plasma membrane estrogen receptors and catecholamine synthesis and secretion in cultured bovine adrenal medullary cells.  Naunyn Schmiedebergs Arch Pharmacol. 2015; 388: 1259-1269 (IF 3.0)
  7. Noda K, Godo S, Saito H, Tsutsui M, Shimokawa H.  Opposing roles of nitric oxide and rho-kinase in lipid metabolism in mice.  Tohoku J Exp Med. 2015; 235: 171-183 (IF 2.547)

2014

  1. Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M. Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol. 2014; 77: 29-41 (IF 5.763)
  2. Kamezaki F, Tsutsui M, Takahashi M, Sonoda S, Kubo T, Fujino Y, Adachi T, Abe H, Takeuchi M, Mayumi T, Otsuji Y. Plasma levels of nitric oxide metabolites are markedly reduced in normotensive males with electrocardiographically determined left ventricular hypertrophy. Hypertension. 2014; 64: 516-522 (IF 9.897)
  3. Hamada T, Souda M, Yoshimura T, Sasaguri S, Hatanaka K, Tasaki T, Yoshioka T, Ohi Y, Yamada S, Tsutsui M, Umekita Y, Tanimoto A. Anti-apoptotic effects of PCP4/PEP19 mediated through the Akt kinase signaling pathway in human breast cancer cells. Oncotarget. 2014; 5: 6076-6086 (IF 5.168)
  4. Ishida M, Shimabukuro M, Yagi S, Nishimoto S, Kozuka C, Fukuda D, Soeki T, Masuzaki H, Tsutsui M, Sata M. MicroRNA-378 regulates adiponectin expression in adipose tissue: a new plausible mechanism. PLoS One. 2014; 9: e111537 (IF 3.752)
  5. Noguchi S, Yatera K, Wang KY, Oda K, Akata K, Yamasaki K, Kawanami T, Ishimoto H, Toyohira Y, Shimokawa H, Yanagihara N, Tsutsui M, Mukae H. Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice. Respir Res 2014; 15: 92 (IF 7.162)
  6. Nobunaga M, Obukuro K, Kurauchi Y, Hisatsune A, Seki T, Tsutsui M, Katsuki H. High fat diet induces specific pathological changes in hypothalamic orexin neurons in mice. Neurochem Int. 2014; 78C: 61-66 (IF 4.297)
  7. Zhang H, Yanagihara N, Toyohira Y, Takahashi K, Inagaki H, Satoh N, Li X, Goa X, Tsutsui M, Takahaishi K. Stimulatory effect of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis through Ser19 and Ser40 phosphorylation of tyrosine hydroxylase in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol. 2014; 387: 15-22 (IF 3.0)
  8. Inagaki H, Toyohira Y, Takahashi K, Ueno S, Obara G, Kawagoe T, Tsutsui M, Hachisuga T, Yanagihara N. Effects of selective estrogen receptor modulators on plasma membrane estrogen receptors and catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. J Pharmacol Sci. 2014; 124: 66-75 (IF 3.578)
  9. Yanagihara N, Zhang H, Toyohira Y, Takahashi K, Ueno S, Tsutsui M, Takahashi K New insights into the pharmacological potential of plant flavonoids in the catecholamine system. J Pharmacol Sci (Review). 2014; 124(2):123-128 (IF 3.578)
  10. Tsutsui M, Shimokawa H, Tanimoto A, Yanagihara N, Otsuji Y. Roles of nitric oxide synthases in arteriosclerotic vascular disease – Insights from murine genetic models -. J Clin Exp Cardiol (Review). 2014; 5: 318 (IF 2.882)

2013

  1. Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Sakanashi M, Uchida T, Tanada M, Kubota H, Arakaki K, Tanimoto A, Yanagihara N, Sakanashi M, Ohya Y, Masuzaki H, Ishiuchi S, Sugahara K, Tsutsui M. Long-Term Treatment with San’o-shashin-to, a Kampo Medicine, Markedly Ameliorates Cardiac Ischemia/Reperfusion Injury in Ovariectomized Rats via the Redox-Dependent Mechanism. Circ J. 2013; 77: 1827-1837 (IF 3.350)
  2. Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H. Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.J Neurosci. 2013; 33: 12557-12568 (IF 6.709)
  3. Sasahara T, Yayama K, Matsuzaki T, Tsutsui M, Okamoto H. Na+/H+ exchanger inhibitor induces vasorelaxation through nitric oxide production in endothelial cells via intracellular acidification-associated Ca2+ mobilization. Vascular Pharmacology. 2013; 58: 319-325 (IF 5.738)
  4. Shibata K, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Nitric oxide synthases and heart failure-Lessons from genetically manipulated mice– J UOEH (Review). 2013; 35(2): 147-158 (IF 0.568)
  5. Yanagihara N, Toyohira Y, Liu M, Ueno S, Tsutsui M, Zhang H. Insights into the pharmacological effects of soy isoflavones on catecholamine system. In: El-Shemy HA, eds. Soybeans and Health. Intech Open Access Publisher, 167-180, 2013

2012

  1. Tsutsui M, Ohya Y, Sugahara K. Latest Evidence in Endothelium-Derived Hyperpolarizing Factor Research. Circ J (Review). 2012; 76: 1599-1600 (IF 3.350)
  2. Obara G, Toyohira Y, Inagaki H, Takahashi K, Horishita T, Kawasaki T, Ueno S, Tsutsui M, Sata T, Yanagihara N. Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells. J Pharmacol Sci. 2013; 121: 138-147 (IF 3.578)
  3. Satoh N, Toyohira Y, Itoh H, Zhang H, Ueno S, Tsutsui M, Takahashi K, Yanagihara N. Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells.Naunyn Schmiedebergs Arch Pharmacol. 2012; 385: 921-931 (IF 3.0)

2011

  1. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I,Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T. Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metabolism 2011; 13: 294-307 (IF 31.373)
  2. Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y. Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein e knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol. 2011; 31: 800-807 (IF 10.514)
  3. Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Uchida T, Arakaki K, Kubota H, Ishiuchi S, Masuzaki H, Sugahara K, Ohya Y, Sakanashi M, Tsutsui M. Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo. Am J Physiol Heart Circ Physiol. 2011; 301: H721-H729 (IF 5.125)
  4. Furuno Y, Morishita T, Toyohira Y, Yamada S, Ueno S, Morisada N, Sugita K, Noguchi K, Sakanashi M, Miyata H, Tanimoto A, Sasaguri Y, Shimokawa H, Otsuji Y, Yanagihara N, Tamura M, Tsutsui M. Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: involvement of bone marrow-derived cells. Nitric Oxide. 2011; 25: 350-359 (IF 4.898)
  5. Kuboyama K, Tsuda M, Tsutsui M, Toyohira Y, Tozaki-Saitoh H, Shimokawa H, Yanagihara N, Inoue K. Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases. Molecular Pain. 2011; 7: 50. doi: 10.1186/1744-8069-7-50. (IF 3.370)

2010

  1. Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N. Pathophysiological relevance of NO signaling in cardiovascular system: novel insight form mice lacking all NO synthases. Pharmacology and Therapeutics (Review). 2010; 128: 499-508 (IF 13.400)
  2. Shimokawa H, Tsutsui M. Nitric oxide synthases in the pathogenesis of cardiovascular disease –Lessons form genetically modified mice–Pflugers Arch – Eur J Physiol (Review). 2010; 459: 959-967 (IF 4.458)
  3. Yatera Y, Shibata K, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Toyohira Y, Wang KY, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Severe dyslipidemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet. Cardiovasc Res. 2010; 87, 675-682 (IF 13.081)
  4. Sugita K, Kabashima K, Yoshiki R, Ikenouchi-Sugita A, Tsutsui M, Nakamura J, Yanagihara N, Tokura Y. Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival. J Invest Dermatol. 2010; 130: 464-471 (IF 7.590)
  5. Zhang H, Toyohira Y, Ueno S, Shinohara Y, Itoh H, Furuno Y, Yamakuni T, Tsutsui M, Takahashi K, Yanagihara N. Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells. J Neurochem. 2010; 114: 1030-1038 (IF 5.546)
  6. Toyohira Y, Ueno S, Tsutsui M, Ito H, Sakai N, Saito N, Takahashi K, Yanagihara N. Stimulatory effects of the soy phytoestrogen genistein on noradrenalin transporter and serotonin transporter activity. Mol Nutr Food Res 2010; 54: 516-524 (IF 6.575)
  7. Shibata K, Yatera Y, Furuno Y, Sabanai K, Morisada N, Nakata S, Morishita T, Yamazaki F, Tanimoto A, Sasaguri Y, Tasaki H, Nakashima Y, Shimokawa H, Yanagihara N, Otsuji Y, Tsutsui M. Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases. Circ J. 2010; 74: 2681-2692 (IF 3.350)
  8. Itoh H, Toyohira Y, Ueno S, Tsutsui M, Takahashi K, Yanagihara N. Upregulation of norepinephrine transporter function by prolonged exposure to nicotine in cultured bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol. 2010; 382: 235-243 (IF 3.0)
  9. Noguchi K, Hamadate N, Matsuzaki T, Sakanashi M, Nakasone J, Sakanashi M, Tsutsui M. Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats. Eur J Pharmacol. 2010; 631: 28-35 (IF 5.195)
  10. Morisada N, Nomura M, Nishii H, Furuno Y, Sakanashi M, Sabanai K, Toyohira Y, Ueno S, Watanabe S, Tamura M, Matsumoto T, Tanimoto A, Sasaguri Y, Shimokawa H, Kusuhara K, Yanagihara N, Shirahata A, Tsutsui M. Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo. J Pharmacol Sci. 2010; 114: 379-389 (IF 3.578)

2009

  1. Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N. Nitric oxide synthases and cardiovascular diseases –Insights form genetically modified mice– Circ J (Review). 2009; 73: 986-993 (IF 3.350)
  2. Ikenouchi-Sugita A, Toyohira Y, Yoshimura R, Ueno S, Tsutsui M, Nakamura J, Yanagihara N. Opposite effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 2009; 380: 479-486 (IF 3.0)

2008

  1. Tsutsui M, Nakata S, Shimokawa H, Otsuji Y, Yanagihara N. Spontaneous myocardial infarction and nitric oxide synthase. Trends Cardiovasc Med (Review). 2008; 18: 275-279 (IF 8.049)
  2. Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K, Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N. Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation. 2008; 117: 2211-2223 (IF 39.918)
  3. Takaki A, Morikawa K, Tsutsui M, Murayama Y, Tekes E, Yamagishi H, Yanagihara N, Shimokawa H. Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J Exp Med. 2008; 205: 2053-2063 (IF 17.579)
  4. Sabanai K, Tsutsui M, Sakai A, Hirasawa H, Tanaka S, Nakamura E, Tanimoto A, Sasaguri Y, Ito M, Shimokawa H, Nakamura T, Yanagihara N. Genetic disruption of all nitric oxide synthase isoforms enhances bone mineral density and bone turnover in mice in vivo: Involvement of the renin-angiotensin system. J Bone Miner Res. 2008; 23(5): 633-643 (IF 6.390)
  5. Kamezaki F, Tasaki H, Yamashita K, Tsutsui M, Koide S, Nakata S, Tanimoto A, Okazaki M, Sasaguri Y, Adachi T, Otsuji Y. Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med. 2008; 177: 219-226 (IF 30.528)
  6. Yamada S, Wang KY, Tanimoto A, Fan J, Shimajiri S, Kitajima S, Tsutsui M, Watanabe T, Yasumoto K, Sasaguri Y. Matrix metalloproteinase 12 is a factor that accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits. Am J Pathol. 2008; 172: 1419-1429 (IF 5.770)
  7. Ulrich M, Petre A, Youhnovski N, Promm F, Schirle M, Schumm M, Pero R, Doyle A, Checkel J, Kita H, Thiyagarajan N, Ravi Acharya K, Schmid-Grendelmeier P, Simon HU, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Doering G. Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. J Biol Chem. 2008; 283(42): 28629-28640 (IF 5.486)
  8. Tanimoto A, Murata Y, Wang KY, Tsutsui M, Kohno K, Sasaguri Y. Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells. J Biol Chem. 2008; 283(8): 4643-4651 (IF 5.486)
  9. Matsuda T, Toyohira Y, Ueno S, Tsutsui M, Yanagihara N. Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells. J Pharmacol Exp Ther. 2008; 327: 1-7 (IF 4.441)
  10. Nagata T, Ueno S, Morita H, Kubota T, Toyohira Y, Tsutsui M, Tawara A, Yanagihara N. Direct inhibition of N methyl-D-aspartate (NMDA) receptor function by antiglaucomatous beta-antagonists. J Pharmacol Sci. 2008; 106: 423-434 (IF 3.578)
  11. Nii H, Tsutsui M, Kondo J, Toyohira Y, Ueno S, Yanagihara N. Copper, zinc superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1,2-a:3’,2’-d]imidazole. Mutat Res (Genet Toxicol Environ Mutagen). 2008; 653: 14-22 (IF 2.107)
  12. Hamadate N, Noguchi K, Sakanashi M, Matsuzaki T, Nakasone J, Sakanashi M. Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats. J Pharmacol Sci. 2008; 107: 49-56. (IF 3.578)

2007

  1. Nakata S, Tsutsui M, Shimokawa H, Yamashita T, Tanimoto A, Tasaki H, Ozumi K, Sabanai K, Morishita T, Suda O, Hirano H, Sasaguri Y, Nakashima Y, Yanagihara N. Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kB pathway. Arterioscler Thromb Vasc Biol.2007; 27(1): 92-98 (IF 10.514)
  2. Tanimoto A, Wang KY, Murata Y, Kimura S, Nomaguchi M, Nakata S, Tsutsui M, Sasaguri Y. Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-kB signaling pathway. Arterioscler Thromb Vasc Biol. 2007; 27: 1556-1561 (IF 10.514)
  3. Hirasawa H, Tanaka S, Sakai A, Tsutsui M, Shimokawa H, Miyata H, Moriwaki S, Niida S, Ito M, Nakamura T. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res. 2007; 22: 1020-1030 (IF 6.390)
  4. Liu M, Yanagihara N, Toyohira Y, Tsutsui M, Ueno S, Shinohara Y. Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells.Endocrinology. 2007; 148(11): 5348-5354 (IF 5.051)
  5. Shinohara Y, Toyohira, Ueno S, Liu M, Tsutsui M, Yanagihara Y. Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells.Biochem Pharmacol. 2007; 74: 1608-1618 (IF 6.100)
  6. Kamezaki F, Tasaki H, Yamashita K, Shibata K, Hirakawa N, Tsutsui M, Kouzuma R, Nagatomo T, Adachi T, Otsuji Y. Angiotensin receptor blocker improves coronary flow velocity reserve in hypertensive patients – comparison with calcium channel blocker. Hypertens Res. 2007; 30: 699-706 (IF 5.573)
  7. Shinkai K, Toyohira Y, Yoshimura R, Tsutsui M, Ueno S, Nakamura J, Yanagihara N. Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran. Naunyn Schmiedebergs Arch Pharmacol. 2007; 375(1): 65-72 (IF 3.0)
  8. Sakanashi M, Sakanashi M, Sugahara K, Sakanashi M. Effects of landiolol on mechanical and metabolic changes in rat reperfused ischaemic hearts. Clin Exp Pharmacol Physiol. 2007; 34: 55-60. (IF 2.963)
  9. Chinen I, Shimabukuro M, Yamakawa K, Higa N, Matsuzaki T, Noguchi K, Ueda S, Sakanashi M, Takasu N. Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology 2007; 148: 160-165. (IF 5.051)

2006

  1. Tsutsui M, Shimokawa H, Morishita T, Nakashima Y, Yanagihara N. Development of genetically engineered mice lacking all nitric oxide synthases. J Pharmacol Sci (Review). 2006; 102: 147-154(IF 3.578)
  2. Tasaki H, Yamashita K, Tsutsui M, Kamezaki F, Kubara T, Tanaka S, Sasaguri Y, Adachi T, Nakashima Y. Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis. Atherosclerosis. 2006; 187: 131-138 (IF 6.847)
  3. Takahashi K, Toyohira T, Ueno S, Tsutsui M, Yanagihara N. Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells. Naunyn Schmiedebergs Arch Pharmacol. 2006; 374(2): 107-116 (IF 3.0)
  4. Suda O, Tsutsui M, Morishita T, Horiuchi M, Nakata S, Kouzuma R, Okazaki M, Sumiyama-Fujinishi A, Mizuki T, Yanagihara N, Tasaki H, Nakashima Y. Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension. J Pharmacol Sci. 2006; 101: 159-165 (IF 3.578)
  5. Akasaka S, Nomura M, Nishii H, Fujimoto N, Ueta Y, Tsutsui M, Shimokawa H, Yanagihara N, Matsumoto T. The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase. Brain Res. 2006; 1089(1): 1-9 (IF 3.610)
  6. Yanagihara N, Liu M, Toyohira Y, Tsutsui M, Ueno S, Shinohara Y, Takahashi K, Tanaka K. Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by 17beta-estradiol. Biochem Biophys Res Commun. 2006; 339: 548-553 (IF 6.300)
  7. Tasaki H, Miyamoto M, Kubara T, Kamezaki F,　Tanaka S, Yamashita K, Tsutsui M, Nakashima Y. Crossover trial of intensive monotherapy with atorvastatin and combined therapy with atorvastatin and colestimide for Japanese familial hypercholesterolemia. Circ J. 2006; 70(1): 14-20 (IF 3.350)
  8. Noguchi K, Matsuzaki T, Ojiri Y, Sakanashi M, Nakasone J, Sakanashi M. Prostacyclin causes splenic dilation and haematological change in dogs. Clin Exp Pharmacol Physiol. 2006; 33: 81-88. (IF 2.963)

2005

  1. Morishita T,* Tsutsui M,* Shimokawa H,* Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N. Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci USA. 2005; 102: 10616-10621 *contributed equally to this work (IF 12.779)
  2. Sasaguri Y, Wang KY, Tanimoto A, Tsutsui M, Ueno H, Murata Y, Kohno Y, Yamada S, Ohtsu H. Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis. Circ Res. 2005; 96(9): 974-981 (IF 23.213)
  3. Nakata S, Tsutsui M, Shimokawa H, Tamura M, Tasaki H, Morishita T, Suda O, Ueno S, Toyohira Y, Nakashima Y, Yanagihara N. Vascular neuronal nitric oxide synthase is selectively upregulated by platelet-derived growth factor: Involvement of the MEK/ERK pathway. Arterioscler Thromb Vasc Biol. 2005; 25(12): 2502-2508 (IF 10.514)
  4. Murata Y, Tanimoto A, Wang KY, Tsutsui M, Sasaguri Y, De Corte F, Matsushita H. Granulocyte macrophage-colony stimulating factor increases the expression of histamine and histamine receptors in monocytes/macrophages in relation to arteriosclerosis. Arterioscler Thromb Vasc Biol. 2005;25(2):430-435 (IF 10.514)
  5. Ozumi K, Tasaki H, Takatsu H, Nakata S, Morishita T, Koide S, Yamashita K, Tsutsui M, Okazaki M, Sasaguri Y, Adachi T, Nakashima Y. Extracellular superoxide dismutase overexpression reduces cuff-induced arterial neointimal formation. Atherosclerosis. 2005; 181: 55-62 (IF 6.847)
  6. Yanagihara N, Toyohira Y, Ueno S, Tsutsui M, Utsunomiya K, Liu M, Tanaka K. Stimulation of catecholamine synthesis by environmental estrogenic pollutants. Endocrinology. 2005; 146(1): 265-272 (IF 5.051)
  7. Shinkai K, Toyohira, Yoshimura R, Ueno S, Tsutsui M, Nakamura J, Yanagihara Y. Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells. Biochem Pharmacol. 2005; 70(9): 1389-1397 (IF 6.100)
  8. Nomura M, Tsutsui M, Shimokawa H, Fujimoto N, Ueta Y, Morishita T, Yanagihara N, Matsumoto T. Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus. Neuroreport. 2005; 16(4): 413-417 (IF 1.703)
  9. Toyohira Y, Kubo T, Watanabe M, Uezono Y, Ueno S, Shinkai K, Tsutsui M, Izumi F, Yanagihara Y. Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure: reduction of catecholamine secretion and synthesis in adrenal medullary cells.Naunyn Schmiedebergs Arch Pharmacol. 2005; 371(2): 107-113 (IF 3.0)
  10. Noguchi K, Sakanashi M, Matsuzaki T, Nakasone J, Sakanashi M, Koyama T, Hamadate N, Sakanashi M. Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats. Toxicon 2005; 45: 519-526.(IF 3.035)