研究業績

Selected publications

  1. Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N.  Pathophysiological relevance of NO signaling in cardiovascular system: novel insight form mice lacking all NO synthases. Pharmacology and Therapeutics (Review). 2010; 128: 499-508 (Impact factor 12.31)
  2. Nakata S, Tsutsui M, Shimokawa H, Suda O, Morishita T, Shibata K, Yatera Y, Sabanai K, Tanimoto A, Nagasaki M, Tasaki H, Sasaguri Y, Nakashima Y, Otsuji Y, Yanagihara N.  Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.  Circulation. 2008; 117: 2211-2223 (Impact factor 29.69)
  3. Suda O, Tsutsui M, Morishita T, Tanimoto A, Horiuchi M, Tasaki H, Huang PL, Sasaguri Y, Yanagihara N, Nakashima Y.  Long-term treatment with Nω-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice.  Circulation. 2002; 106: 1729-1735 (Impact factor 29.69)
  4. Tsutsui M, Milstien S, Katusic ZS.  Effect of tetrahydrobiopterin on endothelial function in canine middle cerebral arteries.  Circ Res. 1996; 79: 336-342 (Impact factor: 17.36)
  5. Chen AF, O’Brien T, Tsutsui M, Kinoshita H, Pompili VJ, Crotty TB, Spector DJ, Katusic ZS.  Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery.  Circ Res. 1997; 80: 327-335 (Impact factor 17.36)
  6. Sasaguri Y, Wang KY, Tanimoto A, Tsutsui M, Ueno H, Murata Y, Kohno Y, Yamada S, Ohtsu H.  Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis. Circ Res. 2005; 96(9): 974-981 (Impact factor 17.36)
  7. Takaki A, Morikawa K, Tsutsui M, Murayama Y, Tekes E, Yamagishi H, Yanagihara N, Shimokawa H.  Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice. J Exp Med. 2008; 205: 2053-2063 (Impact factor 14.307)
  8. Morishita T,* Tsutsui M,* Shimokawa H,* Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N.  Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms.  Proc Natl Acad Sci USA. 2005; 102: 10616-10621 *contributed equally to this work  (Impact factor 11.205)
  9. Chen AF, Jiang SW, Crotty TB, Tsutsui M, Smith LA, O’Brien T, Katusic ZS.  Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries. Proc Natl Acad Sci USA. 1997; 94: 12568-12573 (Impact factor: 11.205)
  10. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.  Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.  Cell Metabolism 2011; 13: 294-307 (Impact factor: 31.373)